Metering: Select what's called Evaluative Metering (it's called Matrix on Nikons).
White Balance: Stick with Automatic (a.k.a. AWB). It's so good, we often find it gives better results on our Certified Lab Tests.
Color Space: If you're planning to color manage your print process and tweak your pictures in an image editor, go with Adobe RGB. If not, you're better off sticking with sRGB, which is normally the default anyway.
Focusing: Use Auto and pick Center. That way, when you're shooting, you can zero in on what you want sharp, hold down the shutter slightly, and then recompose -- just like with your point-and-shoot.