So scientists at the University of Georgia turned to the immature eggs—or oocytes—of female anoles, a type of lizard native to the Caribbean. How did they do it? Lizard surgery, complete with an operating table and anaesthesia. They accessed the anole's ovary and gently injected the CRISPR cocktail into its oocytes. One of the genes modified in the study, which appeared Sunday on the preprint server bioRxiv, targeted the lizards' pigmentation, providing a clear way to see whether or not the splicing worked on the embryos.