Simon, whose past documentary work has included a series on wrongly convicted prisoners ("The Innocents") and another on items detained at U.S. customs and post offices ("Contraband"), is fascinated by the concept of bloodlines. For this project, she spent four years traveling the world, researching, cataloguing, fact-checking, determining an order for, and finally photographing the ascendants and descendants of eighteen individuals and their family trees. She categorized her findings into 18 "chapters," with each corresponding to a single bloodline. They're displayed as a panel that includes a grid of portraits of the "family," a written statement about the bloodline's significance, and supporting photographs acting as narrative elements to the stories she came across in her research. Each includes a numbered key with biographical information about each subject who sat for her.