Sure, you have to deal with dust, film grain, and trickier color correction, but taking your negatives digital is worth the effort
Here’s the most important part—correcting your histogram. Note that you don’t want to do very much fixing or adjusting in the scanner driver. Most of that is best saved for your image editing program. But you do want to make sure you capture all of the data possible so that you are working with all the information possible when you do your editing. Click on the button for the histogram, and, for each channel, drag the triangles outward so that they are placed just beyond the edges of the data. Don’t worry if your image begins to look flat. It’s much easier to add contrast later than to add lost detail.